We show that, given extensive exploration of a three-dimensional volume, grid units can form with the approximate periodicity of a face-centered cubic crystal, as the spontaneous product of a self-organizing process at the single unit level, driven solely by firing rate adaptation.

Older adults often have long-term relationships, and many of their goals are intertwined with their respective partners. Joint goals can help or hinder goal progress. Little is known about how accurately older adults assess if a goal is joint, the role of over-reporting in these perceptions, and how joint goals and over-reporting may relate to older partners' relationship satisfaction and physical health. Two-hundred-thirty-six older adults from 118 couples listed their three most important goals and whether they thought of them as (...) goals they had in common with and wanted to achieve together with their partner. Two independent raters classified goals as “joint” if both partners independently listed open-ended goals of the same content. Goal progress and relationship satisfaction were assessed 1 week later. Allostatic load was calculated using nine different biomarkers. Results show that 85% self-reported at least one goal as joint. Over-reporting– the perception that a goal was joint when in fact it was not mentioned among the three most salient goals of the spouse – occurred in one-third of all goals. Multilevel models indicate that the number of externally-rated joint goals was related to greater goal progress and lower allostatic load, but only for adults with little over-reporting. More joint goals and higher over-reporting were each linked with more relationship satisfaction. In conclusion, joint goals are associated with goal progress, relationship satisfaction, and health, but the association is dependent on the domain of functioning. (shrink)

BackgroundExercise is primarily sustained by energy derived from lipids, and glucose. Substrate utilization is the pattern by which these fuel sources are used during activity. There are many factors that influence substrate utilization. We aim to delineate the effect of exercise intensity and body composition on substrate utilization.ObjectiveThe objective of our study was to discern the differences in substrate utilization profiles during a maximal and submaximal graded exercise test, and to determine the extent to which body composition influences substrate utilization (...) during the exercise tests.MethodsA total of 27 male athletes, 32.5 ± 11 years of age, were recruited for this study. Body composition was analyzed using a bioelectrical impedance analyzer. Maximal and submaximal exercise tests were performed on a treadmill. A novel graded submaximal treadmill protocol was used for the submaximal test.ResultsAverage percent body fat was 15.8 ± 5%. Average maximal oxygen consumption was 47.6 ± 9 mL/kg/min, while the average exercise intensity at which participants were shifting to glucose predominance for energy during the maximal and submaximal tests were 76 ± 8.3% and 58.4 ± 21.1%, respectively. A paired-samples t-test was conducted to compare percent VO2max at crossover point in maximal and submaximal graded exercise tests. There was a significant difference in percent VO2max at the crossover point for maximal and submaximal tests. A linear regression was performed to elucidate the interaction between exercise intensity at the crossover point and body composition during a maximal and submaximal graded exercise test. There was a significant effect of PBF on percent VO2max at crossover point during the maximal graded exercise test [F = 9.10, P = 0.006] with an R2 of 0.245. However, there was no significant effect of PBF on percent VO2max at crossover point during the submaximal graded exercise test.ConclusionSubstrate utilization, represented by the crossover point, is dependent on the rate of increase in exercise intensity. At maximal efforts, the crossover to carbohydrates from fats as the predominant fuel source occurs at a significantly later stage of percent VO2max than at submaximal efforts. Furthermore, body composition represented by PBF is a significant predictor of substrate utilization during maximal efforts. Athletes with a relatively higher PBF are more likely to have increased lipid oxidation during high intensity exercises than those with a lower body fat percentage. (shrink)

Prior research has investigated the recruitment of inhibition in the use of science/mathematics concepts in tasks that require the rejection of a conflicting, nonscientific initial concept. The present research examines if inhibition is the only EF skill recruited in such tasks and investigates whether shifting is also involved. It also investigates whether inhibition and/or shifting are recruited in tasks in which the use of science/mathematics concepts does not require the rejection of an initial concept, or which require only the use (...) of initial concepts. One hundred and thirty‐three third‐ and fifth‐grade children participated in two inhibition and shifting tasks and two science and mathematics conceptual understanding and conceptual change (CU&C) tasks. All the tasks were on‐line, and performance was measured in accuracy and RTs. The CU&C tasks involved the use of initial concepts and of science/mathematics concepts which required conceptual changes for their initial formation. Only in one of the tasks the use of the science/mathematics concepts required the concurrent rejection of an initial concept. The results confirmed that in this task inhibition was recruited and also showed that the speed of shifting was a significant predictor of performance. Shifting was a significant predictor of performance in all the tasks, regardless of whether they involved science/mathematics or initial concepts. It is argued that shifting is likely to be recruited in complex tasks that require multiple comparisons of stimuli and the entertainment of different perspectives. Inhibition seems to be a more selective cognitive skill likely to be recruited when the use of science/mathematics concepts requires the rejection of a conflicting initial concept. (shrink)

In The Metaphysics of Love, however, Stella Sandford argues that an over-emphasis on ethics in the reception of Levinas's thought has concealed the basis and ...

By 1910 the Cambridge University physiology department had become the kernel of British physiology. Between 1909 and 1914 an astonishing number of young and talented scientists passed through the laboratory. The University College department was also a stimulating place of study under the dynamic leadership of Ernest Starling.I have argued that the reasons for this metropolitan axis within British physiology lie with the social structure of late-Victorian and Edwardian higher education. Cambridge, Oxford, and University College London were national institutions attracting (...) students from all over England and Wales. In contrast, the provincial colleges drew their clientele from relatively narrow geographic radii. Generally, also, these institutions were regarded as socially inferior to the longer-established universities.A brief survey of the biographies of some British physiologists demonstrates how physiology, as an occupation, became, over the later decades of the century, socially elite. The scientists who achieved full-time posts in the 1870s generally came from somewhat marginal backgrounds. Foster, like his mentors T. H. Huxley and William Sharpey, came from a non-conformist family. Edward Schäfer was also a dissenter and, like Foster, began his professional career as a general practitioner.Physiologists of the succeeding generation, however, came from wealthy families with established intellectual traditions. John Scott Haldane, nephew of John Burdon Sanderson, was the brother of the politician R. B. Haldane and uncle of the historian A. R. B. Haldane.71 Joseph Barcroft was one of the most affluent of all physiologists.72 His family's wealth derived from linen manufacturing. He attended the Ley's School Cambridge, where his schoolmates included Henry Dale, later Director of the National Institute for Medical Research; F. A. Bainbridge, who eventually became Professor of Physiology at St. Bartholomew's Hospital; and the Cambridge historian J. H. Clapham. A. V. Hill, Professor of Physiology at Manchester and, subsequently, London, married Margaret Keynes, sister of John Maynard Keynes and niece of Sir Walter Langdon Brown, Professor of Physic at Cambridge. Margaret Keynes's younger brother, the surgeon Sir Geoffrey Keynes, married a granddaughter of Charles Darwin; their son Richard Keynes also became a physiologist at Cambridge.These families were part of a new class emerging during the late Victorian period, descendants of the great reforming radicals of the 1830s, who had begun to achieve power through positions in the universities, the professions, and the civil service. Their social prestige rested upon their intellectual expertise. Physiology was an appealing research discipline to these groups because of its clear dissociation from industry and commerce. And because physiology's “practical” face was medicine, its acceptability was reinforced by professional ties.The nature of the Physiological Society confirms this image of physiology as an elite science. By the turn of the century the Society had taken on some of the characteristics of a dining club. The scientific meetings were generally followed by dinner: if the Society met at Oxford, they were entertained at Burdon Sanderson's college, Magdalen.73 Through a “black ball” system, unwanted candidates could be excluded. In 1912, when the question of admitting foreigners was discussed, E. H. Starling wrote to Edward Schäfer: “the Society has very much in it the nature of a club, and a certain amount of personal knowledge of the candidate is always desirable.”74.The developing institutional structure of physiology in late Victorian Britain indicates, therefore, that we must look beyond the achievements of individuals and departments to understand why physiology flourished. The discipline became part of a new social order in which the professional middle classes assumed increasing power. These groups valued intellectual skill, especially in the pure scienes, as forces both for self-advancement and for progress within society. (shrink)

Lagos-based Raypower Radio is one of the very few stations in Nigeria that is offering broadcasts in Nigerian local languages and tribal dialects. Due to the pre-dominant use of English in the education system native Nigerian languages tend to be considered as inferior, especially among social circles of higher education and wealthy background. This research attempts to analyse the influence of parental attitude towards tribal dialects as a barrier or motivational source for Nigerian youth in terms of the use and (...) acquisition of local languages and the reception of radio stations offering local content. (shrink)

Um das Ansehen von medizinischen Forschern ist es in der westlichen Welt nicht überall gut bestellt. In den 1990er-Jahren gelangte das Thema »Medizinischer Forschungsbetrug« erstmals in den USA in das öffentliche Bewusstsein. Eine Debatte um begünstigende Strukturen und denkbare Kontrollinstrumente zur Eindämmung von Missbrauch entbrannte – in Deutschland blieb ein solcher Diskurs bis zur Jahrhundertwende zunächst aus. Der Band nimmt wissenschaftlich arbeitende Ärzte, die ethischen Anforderungen, denen sie sich ausgesetzt sehen, und das System, in dem sie arbeiten, in den Fokus. (...) Stella Elaine Urbans Analyse von Betrugsfällen deckt wissenschaftsimmanente und individuelle Fallstricke auf, die unredliche Forschung begünstigen. Es zeigt sich, dass die wissenschaftliche Integrität unterstützt und geschützt werden muss, um das Vertrauen in die Medizin wiederherzustellen. (shrink)

The argument of this paper hinges on Derrida's relation to Judaism as a religious heritage and/or as an essential experience. If he can be said to ‘appropriate his Jewish roots’ at all, as Colby Dickinson (2011) has recently proposed, this is not because Derrida concurs that all belief in an ultimate reality (‘as such’) must now be understood in merely conditional terms (‘as if’). Rather, it is because Derrida deconstructs the difference between the Jew and the non-Jew, along with the (...) differences between the ‘as if’ and the ‘as such’ and the performative and the constative, in his very demonstration of the impossibility of ‘being-jewish’. Dickinson thus misunderstands the way in which Derrida appropriates Kant's regulative ‘as if’, and thus misrepresents what is at stake in Derrida's ‘faith’ in ‘Jewishness’. What is at stake is what Derrida calls deconstructive responsibility, and it takes the form of a radical fidelity to the principle of reason (to an ‘unconditional theoreticism’). This responsibility, paradoxically, demands and impels the interrogation of critical thinking itself, with its principles, its essences and its identities. Accordingly, Derrida interrupts both the ‘as such’ and the ‘as if’ with the ‘if’ of a dangerous ‘perhaps’. (shrink)

Adult humans show exceptional relational ability relative to other species. In this research, we trace the development of this ability in young children. We used a task widely used in comparative research—the relational match-to-sample task, which requires participants to notice and match the identity relation: for example, AA should match BB instead of CD. Despite the simplicity of this relation, children under 4 years of age failed to pass this test (Experiment 1), and their performance did not improve even with (...) initial feedback (Experiment 2). In Experiments 3 and 4, we found that two kinds of symbolic-linguistic experience can facilitate relational reasoning in young children. Our findings suggest that children learn to become adept analogical thinkers, and that language fosters this learning in at least two distinct ways. (shrink)

In this article, I argue that Habermas’s genealogical approach to modern reason and methodological agnosticism can lead us to a better understanding of the role of religion in our societies. I underline the relevance of Habermas’s awareness that ‘something is missing’ when we take faith out of modernity and consider the truths of philosophical reason to be infallible. Habermas succeeds in highlighting the complexity of the modern relationship between the religious and the secular domains, a relationship that is not merely (...) epistemic, but also embodied in various practical relationships between religious and secular citizens. On this basis, and in the light of Habermas’s idea of modernity as an unfinished project, I argue that religion can be interpreted as a dimension allied to political modernity and democracy as well. (shrink)

Jacques Derrida regularly appeals to an affirmative gesture that is ‘prior’ to or more ‘originary’ than the form of the question, and this suggests one way to understand deconstruction's critical force. The ‘Yes, yes’, he says, situates a ‘vigil or beyond of the question’ with respect to an ‘irreducible responsibility’. Some Derrida scholars therefore construe the double affirmation as a source or ground of critique. In this paper, I refute this suggestion. While an originary ‘Yes, yes’ or ‘come’ (viens) does (...) open the fields of (for example) ‘inheritance’, language, or ‘holistic webs’, I argue, it only marks (will have marked) the processes of différance or of trace that make signification possible in general. No thing, as such, is thereby affirmed. This is why the originary affirmation cannot be said to constitute, in itself, the imperative (il la faut) of the logic (la logique) of ethical-political critique. To explain why a certain ethical imperative can be associated with deconstruction, one must determine why one is always already subject to a vigil that opens critique to its own possibility. One must also determine how the affirmative gesture relates to deconstruction's critical force. (shrink)

IntroductionConcussion is a growing public health concern. No uniformly established therapy exists; neurofeedback studies report treatment value. We use infralow frequency neuromodulation to remediate disabling neurological symptoms caused by traumatic brain injury and noted improved outcomes with a novel concussion protocol. Postconcussion symptoms and persistent postconcussion symptoms are designated timelines for protracted neurological complaints following TBI. We performed a retrospective study to explore effectiveness of ILF in PCS/PPCS and investigated the value of using this concussion protocol.MethodPatients with PCS/PPCS seen for (...) their first neurology office visit or received their first neurofeedback session between 1 August 2018 and 31 January 2021 were entered. Outcomes were compared following treatment as usual vs. TAU with ILF neurotherapy. The study cohort was limited to PPCS patients; the TAU+ILF group was restricted further to PPCS patients receiving at least 10 neurotherapy sessions. Within the TAU+ILF group, comparisons were made between those who trained at least 10 sessions using concussion protocol and those who trained for at least 10 sessions of ILF regardless of protocol.ResultsAmong our resultant PPCS cohort leading persistent neurological complaints were headache, memory impairment, and brain fog. PPCS patients in TAU+ILF+CP demonstrated greater net and percent improvement of symptoms compared to PPCS subjects in TAU. PPCS patients in TAU+ILF-CP trended toward significant symptom improvements compared to TAU, and TAU+ILF+CP trended toward greater efficacy than TAU+ILF-CP.ConclusionPPCS patients who received TAU+ILF+CP demonstrated significantly greater improvement as a group when compared to TAU. When used as an integrative modality to treatment as usual in managing patients with PPCS, ILF neuromodulation with use of concussion protocol provided significant symptom improvements. (shrink)

M. Lipman and P. Freire are two thinkers who support the practice of liberty. Liberty is liberty to learn to think, and to exist in communities of dialogue, questioning, and search. This is the project that leads human beings to understand themselves and recognize others. Without liberty there..

Part way through Stephen Frears’s film, The Queen , the monarch undergoes an extraordinary, magical experience whilstjourneying into the Scottish landscape that surrounds Balmoral, her grandancestral holiday home. Despite the anxious offers from her estate workersto chauffeur her, she drives alone into the mountains and proceeds to breakdown in the centre of a fast flowing river. While awaiting help a strangeevent occurs: a stag appears magically as if from nowhere and, unable tohide her admiration for the beast, the Queen gently (...) utters the words, ‘Oh!You beauty’ before the animal disappears as mysteriously as it arrived.Framed in a painterly way, and providing a marked punctuation to the urbansettings that have dominated the film so far, this short sequence presents aseries of sumptuous landscape images that elicit a spectator response whichis instinctive and intuitive. When analysed using an aesthetic approach – amethodology one might use for the examination of a painting – anemotional relationship is mobilised between the spectator and the film: asentiment not necessarily available through a narrative reading. (shrink)

Merleau-Ponty, Varela, Nagarjuna. Une triangulation possibleDans cet article, on voudrait mettre en évidence une triangulation possible entre Maurice Merleau-Ponty, le biologiste chilien Francisco Varela et le philosophebouddhiste de l’Antiquité Nagarjuna. L’objectif de cette perspective réside dans l’urgence d’une étude de la dynamique du réel, et même de la sensibilité en général.Dans The Embodied Mind, le « projet neuro-phénoménologique » et « l’urgence énactive » de Varela se joignent à la pratique bouddhiste Mahayana de Nagarjuna, à laquelle le biologiste consacre une (...) grande partie de son oeuvre. Ce rapprochement révèle l’intérêt de Varela pour l’ontologie bouddhiste, non substantielle et permanente, ce qui, non seulement le conduit jusqu’aux ultimes conséquences de la chair merleaupontienne, mais accroît aussi sa compréhension de la signification de cette chair.Dans les années précédant le développement de son ontologie, Merleau-Ponty se consacre à l’anthologie intitulée Les philosophes célèbres et décide d’y inclure un chapitre sur la philosophie orientale. Il y montre la nécessité d’un retour à l’Orient en tant qu’il a souvent été le précurseur et le « résonateur de notre rapport avec l’être ». Le présent travail se demande à quoi Merleau-Ponty fait allusion quand il nous invite « à mesurer les possibilités que nous nous sommes fermés en devenant ‘‘occidentaux’’ et, peut-être, à les rouvrir », afin d’établir la possibilité d’une convergence entre la chair, la constitution bouddhiste de la réalité et le projet énactif varélien.Merleau-Ponty, Varela, Nagarjuna. A Possible TriangulationIn this article, we would like to bring to light a possible triangulation between Maurice Merleau-Ponty, the Chilean biologist, Francisco Varela, and the ancientBuddhist philosopher, Nagarjuna. The purpose of doing this lies in the urgency of a study of the dynamic of the real and even of the sensible in general.In The Embodied Mind, Varela’s “neuro-phenomenological project” and the “enactive urgency” are joined to the Nagarjuna’s Mahayana Buddhist practice, to which the biologist devotes a large part of this work. This intersection reveals Varela’s interest in Buddhist ontology, an ontology that is non-substantialist and permanent. It leads not only to the ultimate consequences of Merleau-Ponty’s idea of the flesh, but also it adds its way of understanding to the significance of this flesh.In the years preceding the development of his ontology, Merleau-Ponty devoted himself to the anthology called Les philosophes célèbres. He decides to include in it a chapter on oriental philosophy. He shows there the necessity of a return to the Orient insofar as the East has often been the precursor and the “resonator of our relation to being.” The present work asks to what is Merleau-Ponty alluding when he invites us “to take stock of the possibilities in which we are enclosed by becoming ‘Western’ and perhaps we should reopen these possibilities” in order to establish the possibility of a convergence between the flesh, the Buddhist constitution of reality, and Varela’s enactive project. (shrink)

The emerging area of philosophy of birth is invaluable, first, to diagnose fallacious assumptions about the relation between the womb and reason, and, ultimately, to challenge potentially damaging narratives with major impact on birth care. With its analysis of eighteenth-century epistemic and medical discussions about the role of the uterus in women's reasoning, this article supports two arguments: first, that women's “flawed thinking” was a premise drawn by many modern intellectual men, one that was presented as based upon empirical evidence; (...) and second, that the pervasive construction of the uterus as an element that renders women wild, uncontrollable, and irrational continues to influence contemporary obstetrics, even as today's medicine and science consider themselves to be free of any such prejudices.This article shows the role that Giacomo Casanova played in debunking these prejudices and presents his short manuscript on the issue as an important contribution to the literature of the Enlightenment, with its argument against women's supposed “natural” inferiority and for the idea that differences in education were to blame for women's subordinate position in society.Detailed analysis of the “thinking uterus” debate illuminates the different ways in which various arguments from/by the “anti-uterine” lobby were used to justify the subordination of women: sometimes emphasizing the connection between the uterus and thought and sometimes negating it, but always concluding that women's inferiority is to be found in some known or yet-to-be-discovered anatomical, and mainly sexual, deficiency or problem. (shrink)

This article presents the results of an experiment which investigated elementary school children's explanations of the day/night cycle. First, third, and fifth grade children were asked to explain certain phenomena, such as the disappearance of the sun during the night, the disappearance of stars during the day, the apparent movement of the moon, and the alteration of day and night. The results showed that the majority of the children in our sample used in a consistent fashion a small number of (...) relatively well‐defined mental models of the earth, the sun, and the moon to explain the day/night cycle. These mental models of the day/night cycle were empirically accurate, logically consistent and revealed some sensitivity on the part of the children to issues of simplicity of explanation. The younger children formed Initial mental models which provided explanations of the day/night cycle based on everyday experience (e.g., the sun goes down behind mountains, clouds cover up the sun). The older children constructed synthetic mental models (e.g., the sun and the moon revolve around the stationary earth every 24 hours; the earth rotates in an up/down direction and the sun and moon are fixed on opposite sides) which represented attempts to synthesize the culturally accepted view with aspects of their Initial models. A few of the older children appeared to have constructed a mental model of the day/night cycle similar to the scientific one. A theoretical framework is outlined which explains the formation of initial, synthetic, and scientific models of the day/night cycle in terms of the reinterpretation of a hierarchy of constraints, some of which are present early in the child's life, and others which emerge later out of the structure of the acquired knowledge. (shrink)

This article presents a new argument concerning the relation between Kant’s theory of race and aspects of the critical philosophy. It argues that Kant’s treatment of the problem of the systematic unity of nature and knowledge in the Critique of Pure Reason and the Critique of the Power of Judgment can be traced back a methodological problem in the natural history of the period – that of the possibility of a natural system of nature. Kant’s transformation of the methodological problem (...) from natural history into a set of philosophical problems proceeds by way of the working out of his own problem in natural history – the problem of the natural history of the human races – and specifically the problem of the unity in diversity of the human species, in response to which he develops a theory of race. This theory of race is, further, the first developed model of the use of teleological judgment in Kant’s work. The article thus argues that Kant’s philosophical position on the sy... (shrink)

The current quality assurance culture demands the explicit articulation, by means of publication, of what have been hitherto tacit norms and conventions underlying disciplinary genres. The justification is that publication aids student performance and guarantees transparency and accountability. This requirement makes a number of questionable assumptions predicated upon what we will argue is an erroneous epistemology. It is not always possible to articulate in a publishable form a detailed description of disciplinary practices such as assessment. As a result publication cannot (...) achieve its stated goals. There are always elements of our knowledge that cannot be linguistically articulated. (shrink)

The acquisition of syntactic categories is a crucial step in the process of acquiring syntax. At this stage, before a full grammar is available, only surface cues are available to the learner. Previous computational models have demonstrated that local contexts are informative for syntactic categorization. However, local contexts are affected by sentence-level structure. In this paper, we add sentence type as an observed feature to a model of syntactic category acquisition, based on experimental evidence showing that pre-syntactic children are able (...) to distinguish sentence type using prosody and other cues. The model, a Bayesian Hidden Markov Model, allows for adding sentence type in a few different ways; we find that sentence type can aid syntactic category acquisition if it is used to characterize the differences in word order between sentence types. In these models, knowledge of sentence type permits similar gains to those found by extending the local context. (shrink)

This book is a rich blend of analyses by leading experts from various cultures and disciplines. A compact introduction to a complex field, it illustrates biotechnology's profound impact upon the environment and society. Moreover, it underscores the vital relevance of cultural values. This book empowers readers to more critically assess biotechnology's value and effectiveness within both specific cultural and global contexts.